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NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients NEWS: Tissue-engineered Vascular Grafts Show Promise in Developing Bioengineered Veins
 
NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

HIV infected serodiscordant couples can reduce the risk of transmission by 96% to their partners by initiating oral antiretroviral therapy (ART) when their immune systems are still relatively competent, according to the HIV Prevention Trial Network (HPTN 052) results. Funded by the National Institute of Allergy and Infectious Diseases, the findings were released to the [...]

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Cerclage or cervical stitch has been suggested in cases of cervical insufficiency for the prevention of preterm birth in asymptomatic women with short cervical length. However, randomized trials have reported inconsistent results on the efficacy of cervical cerclage. Now, a recent meta-analysis reaffirms the potential of cervical cerclage in preventing preterm birth, perinatal mortality, and [...]

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

A recent systematic review and meta-analysis published in the British Medical Journal reaffirms the safety, efficacy, and superiority of adrenaline (epinephrine) for better clinical outcomes among outpatients (children less than 2 years of age) with acute bronchiolitis. The study findings also showed evidence on the beneficial effects of adrenaline and dexamethasone combination.

NEWS: Tissue-engineered Vascular Grafts Show Promise in Developing Bioengineered Veins

NEWS: Tissue-engineered Vascular Grafts Show Promise in Developing Bioengineered Veins

A recent research published in the journal Science Translational Medicine reports the development of a new tissue-engineered vascular graft (TEVG) that has shown excellent patency, as well as greater resistance against calcification, intimal hyperplasia, and dilatation. This collaborative effort of scientists from the Yale University, East Carolina University, Duke University, and Humacyte Inc., marks a [...]

Meta-analysis Reaffirms Role of Physical Activity in Attenuating Effect of FTO Risk Allele on Obesity

10 January 2012

The association between physical activity and genetic susceptibility to obesity has already been established by several studies. Now, a recent meta-analysis reiterates the role of physical activity in reducing the association of fat mass- and obesity-associated (FTO) risk allele with the odds of adult BMI and obesity by 27%. The study, published in the recent [...]

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Posted in Basic Sciences, Consumer Health, Diet, Exercise, Genetics0 Comments

Original and Simplified Versions of Wells Rule and Revised Geneva Scores Show Similar Performance in Pulmonary Embolism Evaluation

07 January 2012

The introduction of clinical decision rules (CDRs) has contributed to substantial improvement in the diagnostic work-up of suspected pulmonary embolism (PE) patients. A recent study, touted to be the first one to directly compare the effectiveness of the four CDRs (Wells rule, simplified Wells rule, revised Geneva score [RGS], and simplified RGS) in combination with [...]

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Posted in Cardiology, Chest, Critical Care, Emergency Medicine, Medicine, Pulmonology0 Comments

NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones

03 January 2012

Various alternatives to traditional bearings are being introduced for hip joint replacement in order to decrease implant wear and consequently prolong the time to revision surgery. Despite this, the number of patients undergoing revision surgery within ten years of hip implantation has been substantial. Now, a recent systematic review has observed that the metal-on-metal or [...]

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Posted in Medical Devices, Medical Technology, Medicine, Orthopedics, Surgical Specialties0 Comments

Systematic Review and Dose-response Meta-analysis Highlights the Role of Dietary Interventions in Reducing Colorectal Cancer Risk

22 December 2011

An association between high dietary fiber intake and reduced risk for colorectal cancer has been hypothesized by Burkitt in the 1970s. However, several epidemiological studies have yielded inconclusive results. Now, a systematic review and dose-response meta-analysis provides evidence to validate the link, mainly with the intake of cereal fiber and whole grains.

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Posted in Consumer Health, Diet, Exercise, Medicine, Nutrition, Oncology0 Comments

NEWS: Low Gestational Age at Birth Linked to Mortality in Young Adulthood

13 December 2011

The results of a national cohort study suggest an independent association between low gestational age at birth and increased mortality in early childhood, as well as young adulthood. The study is touted as the first one to report the association.

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Posted in Internal Medicine, Medicine, Neonatology, Obstetrics, Pediatrics0 Comments

Smoking Increases the Risk for Symptomatic Peripheral Artery Disease in Women

25 November 2011

A recent prospective cohort study, published in Annals of Internal Medicine, reports that smoking has a significant causal effect on symptomatic peripheral artery disease (PAD) with subclinical inflammation in women. Although cessation of the habit significantly reduces the risk for PAD, a high incidence of the disease prevails even among previous smokers.

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Posted in Basic Sciences, Cardiology, Gynecology, Internal Medicine, Medicine, Pathology, Women's Health0 Comments

Stepped-care approach 2

Short-term Treatment with NSAIDs Increases Risk for Recurrent Myocardial Infarction or Mortality

17 November 2011

Most patients with established cardiovascular diseases (CVD) receive nonsteroidal anti-inflammatory drugs (NSAIDs) for varied treatment durations despite the associated safety concerns. A recent nationwide cohort study, published in the journal Circulation, provides evidence that even short-term NSAID therapy in patients with previous episodes of myocardial infarction (MI) increases their risk of recurrent MI or death.

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Posted in Basic Sciences, Cardiology, Internal Medicine, Medicine, Pathology, Pharmacology0 Comments

Meta-analysis Reiterates Depression as a Risk Factor for Stroke Morbidity and Mortality

11 November 2011

A recent meta-analysis and systematic review conducted by a team of US researchers provides further evidence to validate the association between depression and enhanced risk of stroke morbidity and mortality.

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Posted in Basic Sciences, Emergency Medicine, Internal Medicine, Medicine, Mental Health, Neurology0 Comments

Study Reports Efficacy of Salpingo-oophorectomy Compared to Cystectomy for Mucinous Borderline Ovarian Tumors

03 November 2011

A recent retrospective cohort study has reported that unilateral salpingo-oophorectomy (USO) rather than cystectomy should be the preferred treatment of choice for patients with mucinous borderline ovarian tumors (MBOTs) during conservative surgery, as the former decreases the recurrence risk and does not hinder fecundity.

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Posted in Fertility, Gynecology, Medical Devices, Medical Technology, Medicine, Obstetrics, Women's Health0 Comments

Swedish Study Reaffirms the Benefit of Mammographic Screening in Reducing Breast Cancer Mortality

31 October 2011

A recent Swedish trial that concluded after a period of three decades reiterates the potential benefit of mammographic screening in reducing breast cancer-specific mortality. The study, published in the recent issue of the journal Radiology, provides evidence to support the recommendation for periodic mammography screening in order to reduce the mortality associated with breast cancer.

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Posted in Medical Devices, Medical Technology, Medicine, Oncology, Radiodiagnosis0 Comments

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