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NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients
 
NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones

NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones

Various alternatives to traditional bearings are being introduced for hip joint replacement in order to decrease implant wear and consequently prolong the time to revision surgery. Despite this, the number of patients undergoing revision surgery within ten years of hip implantation has been substantial. Now, a recent systematic review has observed that the metal-on-metal or [...]

NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

HIV infected serodiscordant couples can reduce the risk of transmission by 96% to their partners by initiating oral antiretroviral therapy (ART) when their immune systems are still relatively competent, according to the HIV Prevention Trial Network (HPTN 052) results. Funded by the National Institute of Allergy and Infectious Diseases, the findings were released to the [...]

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Cerclage or cervical stitch has been suggested in cases of cervical insufficiency for the prevention of preterm birth in asymptomatic women with short cervical length. However, randomized trials have reported inconsistent results on the efficacy of cervical cerclage. Now, a recent meta-analysis reaffirms the potential of cervical cerclage in preventing preterm birth, perinatal mortality, and [...]

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

A recent systematic review and meta-analysis published in the British Medical Journal reaffirms the safety, efficacy, and superiority of adrenaline (epinephrine) for better clinical outcomes among outpatients (children less than 2 years of age) with acute bronchiolitis. The study findings also showed evidence on the beneficial effects of adrenaline and dexamethasone combination.

Matched cohort study cautions about increased risk of mortality with hypnotic use

10 May 2012

Abstract: Chronic insomnia is often associated with substantial socioeconomic and medical ramifications and requires treatment over a prolonged period. However, the long-term use of hypnotics is a matter of intense debate. Evidence suggests that the risks linked to chronic use of hypnotic medication outweigh the benefits. A recent matched cohort study also reports increased mortality [...]

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Posted in Basic Sciences, Cardiology, Internal Medicine, Medicine, Mental Health, Neurology, Patient Care, Pharmacology, Psychiatry, Psychology0 Comments

Inter-arm difference in systolic blood pressure could indicate vascular disease and mortality

27 April 2012

ABSTRACT: Earlier studies have hypothesized an association between inter-arm difference in blood pressure (BP) and peripheral vascular disease. Various guidelines, including those stipulated by the American Heart Association, advocate screening inter-arm BP difference during a patient’s first visit. A recent systematic review and meta-analysis further supports the usefulness of monitoring systolic blood pressure differing by [...]

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Posted in Cardiology, Chest, Internal Medicine, Medicine0 Comments

Study reports negative impact of mammographic breast screening on quality of life

18 April 2012

ABSTRACT: The Forrest Committee report on screening for breast cancer concluded that mammographic screening could be beneficial in prolonging the survival of women ≥50 years of age. Comprehensive systematic reviews conducted on various randomized trials have reported that mammography contributed to a 15-16% reduction in breast cancer mortality. A recent study that updated the modelling [...]

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Posted in Medical Technology, Medicine, Oncology, Women's Health0 Comments

NEWS: Preclinical trial reports efficacy of myocardial-specific hydrogel to treat myocardial infarction

30 March 2012

New percutaneous therapies with materials that mimic the composition of native structural and biochemical matrix are suggested as promising strategies to treat myocardial infarction (MI) and heart failure. A recent preclinical trial published in the Journal of the American College of Cardiology, highlights that transendocardial injection of an in situ gelling material in the rat [...]

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Posted in Basic Sciences, Biotechnology, Biotherapeutics, Cardiology, Medicine, Microbiology0 Comments

Combining patient data with PSA testing to reduce burden of needless prostate biopsies

22 March 2012

ABSTRACT: The introduction of prostate-specific antigen (PSA) testing in 1986 has revolutionized the strategies for early detection and management of prostate cancer. However, a substantial burden of overdiagnosis and over treatment has been attributed to the wider adoption of PSA screening. Evaluation of various parameters in conjunction with PSA level has been suggested to reduce [...]

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Posted in Dental Science, Medical Technology, Medicine, Oncology, Urology0 Comments

NEWS: First clinical trial of implantable microchip shows promising results in drug delivery

21 March 2012

First-in-human testing of a wireless drug delivery microchip reports successful results in administering daily doses of a drug for osteoporosis treatment in lieu of injection.

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Posted in Drug Delivery, Medical Devices, Medical Technology, Medicine, Pharma0 Comments

NEWS: Chemotherapy Induced Mutations Could Influence Leukemia Relapse

10 February 2012

A research team from the Washington University School of Medicine in St Louis has provided evidence to substantiate that chemotherapy plays a role in the relapse of acute myeloid leukemia (AML) through the acquisition of new mutations and clonal evolution.

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Posted in Basic Sciences, Biotechnology, Chemotherapeutics, Genetics, Medicine, Molecular Biology, Oncology0 Comments

Cognitive Behavior Therapy for Psychosis Mediates Symptom Reduction with Corresponding Neural Changes on MRI

01 February 2012

Various psychological therapies have been suggested as adjuvant treatment in managing symptoms of psychosis. Among these, cognitive behavior therapy (CBT) has been shown to be effective, especially for persistent positive symptoms such as delusion. A recent longitudinal study, purported to be the first of its kind, has demonstrated neural changes in the form of reduction [...]

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Posted in Medicine, Mental Health, Neurology, Psychiatry0 Comments

Meta-analysis Reaffirms Role of Physical Activity in Attenuating Effect of FTO Risk Allele on Obesity

10 January 2012

The association between physical activity and genetic susceptibility to obesity has already been established by several studies. Now, a recent meta-analysis reiterates the role of physical activity in reducing the association of fat mass- and obesity-associated (FTO) risk allele with the odds of adult BMI and obesity by 27%. The study, published in the recent [...]

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Posted in Basic Sciences, Consumer Health, Diet, Exercise, Genetics0 Comments

Original and Simplified Versions of Wells Rule and Revised Geneva Scores Show Similar Performance in Pulmonary Embolism Evaluation

07 January 2012

The introduction of clinical decision rules (CDRs) has contributed to substantial improvement in the diagnostic work-up of suspected pulmonary embolism (PE) patients. A recent study, touted to be the first one to directly compare the effectiveness of the four CDRs (Wells rule, simplified Wells rule, revised Geneva score [RGS], and simplified RGS) in combination with [...]

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Posted in Cardiology, Chest, Critical Care, Emergency Medicine, Medicine, Pulmonology0 Comments

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