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Atorvastatin Reduces Ischemic Recurrences after Non-ST-elevation Acute MI in Non-revascularizable CAD Patients ALERT: PROVENGE Receives FDA Approval for Advanced Prostate Cancer Treatment Compound Mimicking BDNF Activities Hold Potential in Developing Novel Class of Neuroprotective Drugs Key Therapeutic Applications of Mesenchymal Stem Cells: A Review of Recent Advances
 
Atorvastatin Reduces Ischemic Recurrences after Non-ST-elevation Acute MI in Non-revascularizable CAD Patients

Atorvastatin Reduces Ischemic Recurrences after Non-ST-elevation Acute MI in Non-revascularizable CAD Patients

Non-ST-elevation acute myocardial infarction (NSTE-AMI) correlates with significantly increased risk of recurrent ischemic events and death, indicating poor prognosis. The results of a recent trial voices the efficacy of full-dose atorvastatin therapy (80 mg/day) in reducing ischemic recurrences following NSTE-AMI in severe, diffuse non-revascularizable coronary artery disease (CAD) patients. The findings of this trial are [...]

ALERT: PROVENGE Receives FDA Approval for Advanced Prostate Cancer Treatment

ALERT: PROVENGE Receives FDA Approval for Advanced Prostate Cancer Treatment

The U.S. Food and Drug Administration (FDA) has granted approval for PROVENGE® (sipuleucel-T | Dendreon Corporation) for treating asymptomatic or minimally symptomatic, metastatic, hormone-resistant (castrate-resistant) prostate cancer (CRPC). It acts by eliciting an immune response against a prostate cancer-specific antigen, prostatic acid phosphatase (PAP). The drug formulated from patient-specific white blood cells, is not indicated [...]

Compound Mimicking BDNF Activities Hold Potential in Developing Novel Class of Neuroprotective Drugs

Compound Mimicking BDNF Activities Hold Potential in Developing Novel Class of Neuroprotective Drugs

Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, is reported as a crucial mediator of neurogenesis, neuronal survival, differentiation and synaptic plasticity. Several studies have suggested the therapeutic benefits of administering the neurotrophic factor for treating various neurologic disorders. Now, a recent study published in the journal PNAS [...]

Key Therapeutic Applications of Mesenchymal Stem Cells: A Review of Recent Advances

Key Therapeutic Applications of Mesenchymal Stem Cells: A Review of Recent Advances

In recent years, mesenchymal stem cell (MSC) research has witnessed significant advancements with regard to isolation, characterization, and regulation of differentiation. Reported to occur in diverse adult tissues, including bone marrow, adipose tissue, and cord blood, MSCs hold great therapeutic interest in the field of cell-based tissue engineering and regeneration.

NEWS: Botox Treatment Linked to Limited Emotional Experience

02 September 2010

Several studies have validated the safety, tolerability, and efficacy profiles of botulinum toxin injection (Botox) for various therapeutic as well as esthetic indications. In contrast to these findings, a recent study published in the journal Emotion reports that the injection may adversely affect the emotional experience of the treated subjects.

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Posted in Clinical Research, Consumer Health, Medicine, Pharma, Women's Health0 Comments

NEWS: Intensive Therapies for Hyperglycemia and Dyslipidemia may Reduce Diabetic Retinopathy Progression Rate

24 August 2010

Earlier studies have substantiated the role of diverse systemic factors, including hyperglycemia, dyslipidemia, and hypertension, in the development and progression of diabetic retinopathy. Now, the results of a randomized trial, conducted by the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group and ACCORD Eye Study Group reports that intensive glycemic control and a [...]

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Posted in Basic Sciences, Diabetes, Endocrinology, Medicine, Ophthalmology0 Comments

Diabetes Linked to Enhanced Risk of Second Primary Breast Cancer

12 August 2010

Previous studies have suggested a direct association between hyperinsulinemia and mammalian carcinogenesis. Now, a recent population-based nested case-controlled study, published in the journal Breast Cancer Research and Treatment, concludes an elevated risk for contralateral breast cancer (CBC) in diabetics diagnosed with primary breast cancer, perhaps indicating the need for additional screening of breast cancer survivors.

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Posted in Diabetes, Endocrinology, Medicine, Oncology, Women's Health0 Comments

Influenza Vaccine Patch Containing Dissolvable Needles Developed

07 August 2010

A team of researchers at the Emory University and Georgia Institute of Technology have designed a novel influenza-vaccine patch containing numerous vaccine-filled, dissolvable micron-scale needles, which facilitate painless intradermal administration. Enabling self-administration, the patch is reported to be easy-to-use, aiding in large-scale immunization programs, especially in developing countries. The promising findings of the study are [...]

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Posted in Basic Sciences, Immunology, Infectious Diseases, Medicine, Microbiology, Pathology, Virology0 Comments

Study Reiterates Importance of Preimplantation Factor for Successful Pregnancy

07 August 2010

Preimplantation factor (PIF), a 15 amino acid peptide secreted by viable embryos, is reported to play a crucial role in embryo implantation as well as achievement of maternal tolerance via local and systemic immunomodulation. Now, a recent genomic and proteomic study has provided further credence to the positive influence of PIF in embryo attachment and [...]

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Posted in Biotechnology, Clinical Research, Genomics, Gynecology, Internal Medicine, Medicine, Molecular Biology, Pharma, Women's Health0 Comments

ALERT: Psychotropic Drugs Could Raise Birth Defect Risk During Pregnancy

29 July 2010

A recent study by Danish researchers has reported that the intake of psychotropic medications could pose serious adverse effects during pregnancy, including the possibility of birth defects in the offspring. The findings of the study are published in the recent issue of the open access journal BMC Research Notes.

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Posted in Basic Sciences, Consumer Health, Gynecology, Medicine, Mental Health, Neonatology, Obstetrics, Parenting, Pharmacology, Psychiatry, Psychology0 Comments

ALERT: Simple Blood Test Could Help Predict Age at Menopause

29 July 2010

A recent breakthrough study reports the development of a blood test that helps predict the approximate age at which a woman would attain menopause. The findings of this population-based cohort study were presented at the 26th annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) held at Rome from 27th to 30th [...]

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Posted in Endocrinology, Gynecology, Medicine, Obstetrics, Women's Health0 Comments

Teriflunomide and Glatiramer Acetate Combination Safe and Effective Against Relapsing-remitting MS

23 July 2010

The current long-term therapies used to treat multiple sclerosis (MS) are administered intramuscularly or subcutaneously, producing local adverse effects at the sites of injection. Hence, the development of an orally administered drug would offer greater convenience and be more acceptable to patients. Teriflunomide is one of five such orally administered disease-modifying agents (used against rheumatoid [...]

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Posted in Basic Sciences, Clinical Research, Drug Delivery, Drug Development, Medicine, Neurology, Pharma, Pharmacology0 Comments

ALERT: Study Suggests Allopurinol to be Safe and Effective Anti-ischemic Drug

13 July 2010

Allopurinol, the prototype xanthine oxidase inhibitor, has been indicated for the management of gout and other conditions associated with hyperuricemia for more than half a century. Recent reports have suggested the probable role of xanthine oxidase in ischemic injuries, thereby prompting researchers to consider allopurinol as a treatment option. Now, a recent double-blind, randomized, placebo-controlled, [...]

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Posted in After 60, Basic Sciences, Cardiology, Consumer Health, Geriatrics, Medicine, Pharmacology0 Comments

Inhibition of LDL Recognition by T cells Suggested as Potential Strategy for Atherosclerosis Vaccines

02 July 2010

Numerous studies have proposed that the immune reaction to oxidized low-density lipoprotein (oxLDL) plays a crucial role in the different phases of atherosclerosis. Reporting that T cells attack normal LDL rather than the oxLDL molecules, a recent breakthrough study suggests that blocking the LDL-recognizing T cell receptors could seize the T cell’s response to LDL, [...]

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Posted in Basic Sciences, Biochemistry, Biotechnology, Biotherapeutics, Cardiology, Immunology, Molecular Biology, Pathology0 Comments

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