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NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients
 
NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones

NEWS: Systematic Review Reports that Newer Hip Implant Bearings are Not Better than Traditional Ones

Various alternatives to traditional bearings are being introduced for hip joint replacement in order to decrease implant wear and consequently prolong the time to revision surgery. Despite this, the number of patients undergoing revision surgery within ten years of hip implantation has been substantial. Now, a recent systematic review has observed that the metal-on-metal or [...]

NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

NEWS: HPTN 052 Results Advocate Antiretroviral Treatment to Prevent HIV Transmission in Serodiscordant Couples

HIV infected serodiscordant couples can reduce the risk of transmission by 96% to their partners by initiating oral antiretroviral therapy (ART) when their immune systems are still relatively competent, according to the HIV Prevention Trial Network (HPTN 052) results. Funded by the National Institute of Allergy and Infectious Diseases, the findings were released to the [...]

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Meta-analysis Reiterates Benefits of Cervical Cerclage in Preventing Preterm Birth, Perinatal Mortality and Morbidity

Cerclage or cervical stitch has been suggested in cases of cervical insufficiency for the prevention of preterm birth in asymptomatic women with short cervical length. However, randomized trials have reported inconsistent results on the efficacy of cervical cerclage. Now, a recent meta-analysis reaffirms the potential of cervical cerclage in preventing preterm birth, perinatal mortality, and [...]

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

Meta-analysis Substantiates the Safety and Efficacy of Adrenaline for Acute Bronchiolitis in Pediatric Patients

A recent systematic review and meta-analysis published in the British Medical Journal reaffirms the safety, efficacy, and superiority of adrenaline (epinephrine) for better clinical outcomes among outpatients (children less than 2 years of age) with acute bronchiolitis. The study findings also showed evidence on the beneficial effects of adrenaline and dexamethasone combination.

NEWS: Pinopodes proposed to play a novel role in the initial stages of embryo-endometrial apposition and adhesion

22 August 2012

The key components required to initiate molecular interactions between the endometrium and blastocysts have been shown to be present in the apical surface of the endometrium. Previous studies have reported that the L-selectin adhesion system, comprising of L-selectin and its oligosaccharide ligands, could be regarded as one of the vital pathways mediating these preliminary interactions. [...]

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Posted in Fertility, Gynecology, Medicine0 Comments

NEWS: Study suggests cardiovascular benefits of exenatide in type 2 diabetics with congestive heart failure

20 June 2012

Emerging evidence suggest the cardioprotective effects of glucagon-like peptide 1 receptor (GLP-1R) agonists beyond glycemic control such as regulation of vascular tone, blood pressure, heart rate, and myocardial contractility. A recent, double-blind, randomized controlled clinical trial reports that infusion of exenatide, a GLP-1R agonist, substantially increases the cardiac index (CI), due to chronotropy in type [...]

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Posted in Cardiology, Clinical Research, Diabetes, Medicine, Pharma0 Comments

NEWS: Intrauterine exposure to mild analgesics may increase risk of cryptorchidism

07 June 2012

Previous trials have indicated an elevated risk of reproductive disorders in children with maternal use of over-the-counter mild analgesics during pregnancy. Now, a large, population-based, prospective birth cohort study (Generation R Study) reiterates that intrauterine exposure to mild analgesics, especially paracetamol, during the period of male sexual differentiation may be linked to increased risk of [...]

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Posted in Fertility, Fetal Medicine, Gynecology, Internal Medicine, Medicine, Pharmacology, Women's Health0 Comments

High prepregnancy BMI linked to adverse pregnancy outcomes in type 1 diabetics

19 May 2012

ABSTRACT: There is substantial evidence to validate the role of gestational diabetes, obesity, and overweight in increasing the risk of obstetric and perinatal complications. An intriguing association between maternal prepregnancy BMI and risk of adverse pregnancy outcomes has been reported recently for the first time in subjects with type 1 diabetes, based on BMI [...]

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Posted in Diabetes, Gynecology, Medicine, Obstetrics, Women's Health0 Comments

Matched cohort study cautions about increased risk of mortality with hypnotic use

10 May 2012

Abstract: Chronic insomnia is often associated with substantial socioeconomic and medical ramifications and requires treatment over a prolonged period. However, the long-term use of hypnotics is a matter of intense debate. Evidence suggests that the risks linked to chronic use of hypnotic medication outweigh the benefits. A recent matched cohort study also reports increased mortality [...]

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Posted in Basic Sciences, Cardiology, Internal Medicine, Medicine, Mental Health, Neurology, Patient Care, Pharmacology, Psychiatry, Psychology0 Comments

Inter-arm difference in systolic blood pressure could indicate vascular disease and mortality

27 April 2012

ABSTRACT: Earlier studies have hypothesized an association between inter-arm difference in blood pressure (BP) and peripheral vascular disease. Various guidelines, including those stipulated by the American Heart Association, advocate screening inter-arm BP difference during a patient’s first visit. A recent systematic review and meta-analysis further supports the usefulness of monitoring systolic blood pressure differing by [...]

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Posted in Cardiology, Chest, Internal Medicine, Medicine0 Comments

Study reports negative impact of mammographic breast screening on quality of life

18 April 2012

ABSTRACT: The Forrest Committee report on screening for breast cancer concluded that mammographic screening could be beneficial in prolonging the survival of women ≥50 years of age. Comprehensive systematic reviews conducted on various randomized trials have reported that mammography contributed to a 15-16% reduction in breast cancer mortality. A recent study that updated the modelling [...]

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Posted in Medical Technology, Medicine, Oncology, Women's Health0 Comments

NEWS: Preclinical trial reports efficacy of myocardial-specific hydrogel to treat myocardial infarction

30 March 2012

New percutaneous therapies with materials that mimic the composition of native structural and biochemical matrix are suggested as promising strategies to treat myocardial infarction (MI) and heart failure. A recent preclinical trial published in the Journal of the American College of Cardiology, highlights that transendocardial injection of an in situ gelling material in the rat [...]

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Posted in Basic Sciences, Biotechnology, Biotherapeutics, Cardiology, Medicine, Microbiology0 Comments

Combining patient data with PSA testing to reduce burden of needless prostate biopsies

22 March 2012

ABSTRACT: The introduction of prostate-specific antigen (PSA) testing in 1986 has revolutionized the strategies for early detection and management of prostate cancer. However, a substantial burden of overdiagnosis and over treatment has been attributed to the wider adoption of PSA screening. Evaluation of various parameters in conjunction with PSA level has been suggested to reduce [...]

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Posted in Dental Science, Medical Technology, Medicine, Oncology, Urology0 Comments

NEWS: First clinical trial of implantable microchip shows promising results in drug delivery

21 March 2012

First-in-human testing of a wireless drug delivery microchip reports successful results in administering daily doses of a drug for osteoporosis treatment in lieu of injection.

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Posted in Drug Delivery, Medical Devices, Medical Technology, Medicine, Pharma0 Comments

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